Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes

Substantial efforts have been devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. This work describes a copper-catalyzed asymmetric synthesis of exocyclic allenes by simultaneous control of axial and central chirality.

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Main Authors:	Cheng-Yu He, Yun-Xuan Tan, Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao, Ping Tian, Guo-Qiang Lin
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/f7b8036d46844e46b07e688aa2c62b34
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spelling	oai:doaj.org-article:f7b8036d46844e46b07e688aa2c62b342021-12-02T15:09:26ZCopper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes10.1038/s41467-020-18136-x2041-1723https://doaj.org/article/f7b8036d46844e46b07e688aa2c62b342020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18136-xhttps://doaj.org/toc/2041-1723Substantial efforts have been devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. This work describes a copper-catalyzed asymmetric synthesis of exocyclic allenes by simultaneous control of axial and central chirality.Cheng-Yu HeYun-Xuan TanXin WangRui DingYi-Fan WangFeng WangDingding GaoPing TianGuo-Qiang LinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng-Yu He Yun-Xuan Tan Xin Wang Rui Ding Yi-Fan Wang Feng Wang Dingding Gao Ping Tian Guo-Qiang Lin Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
description	Substantial efforts have been devoted to the construction of axially chiral allenes, however, the strategies to prepare chiral exocyclic allenes are still rare. This work describes a copper-catalyzed asymmetric synthesis of exocyclic allenes by simultaneous control of axial and central chirality.
format	article
author	Cheng-Yu He Yun-Xuan Tan Xin Wang Rui Ding Yi-Fan Wang Feng Wang Dingding Gao Ping Tian Guo-Qiang Lin
author_facet	Cheng-Yu He Yun-Xuan Tan Xin Wang Rui Ding Yi-Fan Wang Feng Wang Dingding Gao Ping Tian Guo-Qiang Lin
author_sort	Cheng-Yu He
title	Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
title_short	Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
title_full	Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
title_fullStr	Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
title_full_unstemmed	Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
title_sort	copper(i)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7b8036d46844e46b07e688aa2c62b34
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Copper(I)-catalyzed diastereo- and enantio-selective construction of optically pure exocyclic allenes

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