Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.
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Nature Portfolio
2017
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oai:doaj.org-article:f7c9d14db1d44c6a865877ade1d179332021-12-02T17:06:21ZLarge scale meta-analysis characterizes genetic architecture for common psoriasis associated variants10.1038/ncomms153822041-1723https://doaj.org/article/f7c9d14db1d44c6a865877ade1d179332017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15382https://doaj.org/toc/2041-1723Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals.Lam C. TsoiPhilip E. StuartChao TianJohann E. GudjonssonSayantan DasMatthew ZawistowskiEva EllinghausJonathan N. BarkerVinod ChandranNick DandKristina Callis DuffinCharlotta EnerbäckTõnu EskoAndre FrankeDafna D. GladmanPer HoffmannKülli KingoSulev KõksGerald G. KruegerHenry W. LimAndres MetspaluUlrich MrowietzSören MuchaProton RahmanAndre ReisTrilokraj TejasviRichard TrembathJohn J. VoorheesStephan WeidingerMichael WeichenthalXiaoquan WenNicholas ErikssonHyun M. KangDavid A. HindsRajan P. NairGonçalo R. AbecasisJames T ElderNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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EN |
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Science Q Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| description |
Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder and colleagues identify 16 novel psoriasis susceptibility loci using GWAS meta-analysis with a combined effective sample size of over 39,000 individuals. |
| format |
article |
| author |
Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder |
| author_facet |
Lam C. Tsoi Philip E. Stuart Chao Tian Johann E. Gudjonsson Sayantan Das Matthew Zawistowski Eva Ellinghaus Jonathan N. Barker Vinod Chandran Nick Dand Kristina Callis Duffin Charlotta Enerbäck Tõnu Esko Andre Franke Dafna D. Gladman Per Hoffmann Külli Kingo Sulev Kõks Gerald G. Krueger Henry W. Lim Andres Metspalu Ulrich Mrowietz Sören Mucha Proton Rahman Andre Reis Trilokraj Tejasvi Richard Trembath John J. Voorhees Stephan Weidinger Michael Weichenthal Xiaoquan Wen Nicholas Eriksson Hyun M. Kang David A. Hinds Rajan P. Nair Gonçalo R. Abecasis James T Elder |
| author_sort |
Lam C. Tsoi |
| title |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_short |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_full |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_fullStr |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_full_unstemmed |
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| title_sort |
large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/f7c9d14db1d44c6a865877ade1d17933 |
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