Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection

Thoracic aortic dissection has a high fatality rate and no effective treatment. Here, the authors develop cationic nanoparticles for the delivery of miR-145 and show that they stabilize vascular structures and prevent further deterioration of the aorta in mouse models of the disease.

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Autores principales:	Chen Xu, Yanzhenzi Zhang, Ke Xu, Jing-Jun Nie, Bingran Yu, Sijin Li, Gang Cheng, Yulin Li, Jie Du, Fu-Jian Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7cf82f1599a4b6b86b79b2f7774664c
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spelling	oai:doaj.org-article:f7cf82f1599a4b6b86b79b2f7774664c2021-12-02T16:57:33ZMultifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection10.1038/s41467-019-11068-12041-1723https://doaj.org/article/f7cf82f1599a4b6b86b79b2f7774664c2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11068-1https://doaj.org/toc/2041-1723Thoracic aortic dissection has a high fatality rate and no effective treatment. Here, the authors develop cationic nanoparticles for the delivery of miR-145 and show that they stabilize vascular structures and prevent further deterioration of the aorta in mouse models of the disease.Chen XuYanzhenzi ZhangKe XuJing-Jun NieBingran YuSijin LiGang ChengYulin LiJie DuFu-Jian XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Xu Yanzhenzi Zhang Ke Xu Jing-Jun Nie Bingran Yu Sijin Li Gang Cheng Yulin Li Jie Du Fu-Jian Xu Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
description	Thoracic aortic dissection has a high fatality rate and no effective treatment. Here, the authors develop cationic nanoparticles for the delivery of miR-145 and show that they stabilize vascular structures and prevent further deterioration of the aorta in mouse models of the disease.
format	article
author	Chen Xu Yanzhenzi Zhang Ke Xu Jing-Jun Nie Bingran Yu Sijin Li Gang Cheng Yulin Li Jie Du Fu-Jian Xu
author_facet	Chen Xu Yanzhenzi Zhang Ke Xu Jing-Jun Nie Bingran Yu Sijin Li Gang Cheng Yulin Li Jie Du Fu-Jian Xu
author_sort	Chen Xu
title	Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
title_short	Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
title_full	Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
title_fullStr	Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
title_full_unstemmed	Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
title_sort	multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f7cf82f1599a4b6b86b79b2f7774664c
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_version_	1718382541455491072

Multifunctional cationic nanosystems for nucleic acid therapy of thoracic aortic dissection

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