Developmental potential of aneuploid human embryos cultured beyond implantation

Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 embryos, and trophoblast hypo-proliferation in tr...

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Autores principales:	Marta N. Shahbazi, Tianren Wang, Xin Tao, Bailey A. T. Weatherbee, Li Sun, Yiping Zhan, Laura Keller, Gary D. Smith, Antonio Pellicer, Richard T. Scott, Emre Seli, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f7ed59a03a7948919b6f685226479c9b
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spelling	oai:doaj.org-article:f7ed59a03a7948919b6f685226479c9b2021-12-02T15:07:56ZDevelopmental potential of aneuploid human embryos cultured beyond implantation10.1038/s41467-020-17764-72041-1723https://doaj.org/article/f7ed59a03a7948919b6f685226479c9b2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17764-7https://doaj.org/toc/2041-1723Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 embryos, and trophoblast hypo-proliferation in trisomy 16 embryos.Marta N. ShahbaziTianren WangXin TaoBailey A. T. WeatherbeeLi SunYiping ZhanLaura KellerGary D. SmithAntonio PellicerRichard T. ScottEmre SeliMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marta N. Shahbazi Tianren Wang Xin Tao Bailey A. T. Weatherbee Li Sun Yiping Zhan Laura Keller Gary D. Smith Antonio Pellicer Richard T. Scott Emre Seli Magdalena Zernicka-Goetz Developmental potential of aneuploid human embryos cultured beyond implantation
description	Aneuploidy, abnormal chromosome number, is a major cause of early pregnancy loss. Here the authors determine the extent of post-implantation development of human embryos with common aneuploidies in culture, finding developmental arrest of monosomy 21 embryos, and trophoblast hypo-proliferation in trisomy 16 embryos.
format	article
author	Marta N. Shahbazi Tianren Wang Xin Tao Bailey A. T. Weatherbee Li Sun Yiping Zhan Laura Keller Gary D. Smith Antonio Pellicer Richard T. Scott Emre Seli Magdalena Zernicka-Goetz
author_facet	Marta N. Shahbazi Tianren Wang Xin Tao Bailey A. T. Weatherbee Li Sun Yiping Zhan Laura Keller Gary D. Smith Antonio Pellicer Richard T. Scott Emre Seli Magdalena Zernicka-Goetz
author_sort	Marta N. Shahbazi
title	Developmental potential of aneuploid human embryos cultured beyond implantation
title_short	Developmental potential of aneuploid human embryos cultured beyond implantation
title_full	Developmental potential of aneuploid human embryos cultured beyond implantation
title_fullStr	Developmental potential of aneuploid human embryos cultured beyond implantation
title_full_unstemmed	Developmental potential of aneuploid human embryos cultured beyond implantation
title_sort	developmental potential of aneuploid human embryos cultured beyond implantation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f7ed59a03a7948919b6f685226479c9b
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_version_	1718388359506690048

Developmental potential of aneuploid human embryos cultured beyond implantation

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