Development of selective bispecific Wnt mimetics for bone loss and repair

Development of selective bispecific Wnt mimetics for bone loss and repair

Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when administered after fracture.

Saved in:
Bibliographic Details
Main Authors: Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/f832347476cc4872864883076749da99
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/f832347476cc4872864883076749da99

Similar Items