Development of selective bispecific Wnt mimetics for bone loss and repair

Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when administered after fracture.

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Autores principales:	Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f832347476cc4872864883076749da99
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spelling	oai:doaj.org-article:f832347476cc4872864883076749da992021-12-02T18:24:57ZDevelopment of selective bispecific Wnt mimetics for bone loss and repair10.1038/s41467-021-23374-82041-1723https://doaj.org/article/f832347476cc4872864883076749da992021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23374-8https://doaj.org/toc/2041-1723Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when administered after fracture.Tristan W. FowlerTroy L. MitchellClaudia Y. JandaLiqin XieShengjiang TuHui ChenHaili ZhangJingjing YeBrian OuyangTom Z. YuanSung-Jin LeeMaureen NewmanNikita TripuraneniErica S. RegoDevin MuthaArchana DilipMeghah VuppalapatyHelene BaribaultWen-Chen YehYang LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tristan W. Fowler Troy L. Mitchell Claudia Y. Janda Liqin Xie Shengjiang Tu Hui Chen Haili Zhang Jingjing Ye Brian Ouyang Tom Z. Yuan Sung-Jin Lee Maureen Newman Nikita Tripuraneni Erica S. Rego Devin Mutha Archana Dilip Meghah Vuppalapaty Helene Baribault Wen-Chen Yeh Yang Li Development of selective bispecific Wnt mimetics for bone loss and repair
description	Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when administered after fracture.
format	article
author	Tristan W. Fowler Troy L. Mitchell Claudia Y. Janda Liqin Xie Shengjiang Tu Hui Chen Haili Zhang Jingjing Ye Brian Ouyang Tom Z. Yuan Sung-Jin Lee Maureen Newman Nikita Tripuraneni Erica S. Rego Devin Mutha Archana Dilip Meghah Vuppalapaty Helene Baribault Wen-Chen Yeh Yang Li
author_facet	Tristan W. Fowler Troy L. Mitchell Claudia Y. Janda Liqin Xie Shengjiang Tu Hui Chen Haili Zhang Jingjing Ye Brian Ouyang Tom Z. Yuan Sung-Jin Lee Maureen Newman Nikita Tripuraneni Erica S. Rego Devin Mutha Archana Dilip Meghah Vuppalapaty Helene Baribault Wen-Chen Yeh Yang Li
author_sort	Tristan W. Fowler
title	Development of selective bispecific Wnt mimetics for bone loss and repair
title_short	Development of selective bispecific Wnt mimetics for bone loss and repair
title_full	Development of selective bispecific Wnt mimetics for bone loss and repair
title_fullStr	Development of selective bispecific Wnt mimetics for bone loss and repair
title_full_unstemmed	Development of selective bispecific Wnt mimetics for bone loss and repair
title_sort	development of selective bispecific wnt mimetics for bone loss and repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f832347476cc4872864883076749da99
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Development of selective bispecific Wnt mimetics for bone loss and repair

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