Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro fertilization (IVF), suggesting an approach to reduce...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yue Huang, Zhiling Li, En Lin, Pei He, Gaizhen Ru
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/f84694a74b4645d9954964ac38c1c111
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f84694a74b4645d9954964ac38c1c111
record_format	dspace
spelling	oai:doaj.org-article:f84694a74b4645d9954964ac38c1c1112021-12-05T12:24:26ZOxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos10.1038/s12276-021-00700-01226-36132092-6413https://doaj.org/article/f84694a74b4645d9954964ac38c1c1112021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00700-0https://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro fertilization (IVF), suggesting an approach to reduce this risk. In studies on IVF mouse embryos, Zhiling Li and colleagues at First Affiliated Hospital of Shantou University Medical College in China found that harmful effects of natural oxidizing agents induced overproduction of specific protein components of ribosomes. This increased the embryos’ susceptibility to tumorigenesis through a particular molecular signaling pathway. Exposure to the natural antioxidant chemical epigallocatechin-3-gallate (EGCG) corrected the overproduction and protected the embryos. EGCG, found in green tea, is being widely investigated for its anticancer effects. Exposing embryos to EGCG during IVF might protect the resulting children from increased risk of tumor formation in later life.Yue HuangZhiling LiEn LinPei HeGaizhen RuNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1792-1806 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Yue Huang Zhiling Li En Lin Pei He Gaizhen Ru Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
description	IVF: Mechanism and correction of increased cancer risk Increased production of ribosomes, the multi-molecular structures inside cells where protein synthesis occurs, is implicated in the enhanced risk of cancer in offspring conceived by in vitro fertilization (IVF), suggesting an approach to reduce this risk. In studies on IVF mouse embryos, Zhiling Li and colleagues at First Affiliated Hospital of Shantou University Medical College in China found that harmful effects of natural oxidizing agents induced overproduction of specific protein components of ribosomes. This increased the embryos’ susceptibility to tumorigenesis through a particular molecular signaling pathway. Exposure to the natural antioxidant chemical epigallocatechin-3-gallate (EGCG) corrected the overproduction and protected the embryos. EGCG, found in green tea, is being widely investigated for its anticancer effects. Exposing embryos to EGCG during IVF might protect the resulting children from increased risk of tumor formation in later life.
format	article
author	Yue Huang Zhiling Li En Lin Pei He Gaizhen Ru
author_facet	Yue Huang Zhiling Li En Lin Pei He Gaizhen Ru
author_sort	Yue Huang
title	Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
title_short	Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
title_full	Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
title_fullStr	Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
title_full_unstemmed	Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos
title_sort	oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the wnt and tgf-β1 pathways in ivf embryos
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/f84694a74b4645d9954964ac38c1c111
work_keys_str_mv	AT yuehuang oxidativedamageinducedhyperactiveribosomebiogenesisparticipatesintumorigenesisofoffspringbycrossinteractingwiththewntandtgfb1pathwaysinivfembryos AT zhilingli oxidativedamageinducedhyperactiveribosomebiogenesisparticipatesintumorigenesisofoffspringbycrossinteractingwiththewntandtgfb1pathwaysinivfembryos AT enlin oxidativedamageinducedhyperactiveribosomebiogenesisparticipatesintumorigenesisofoffspringbycrossinteractingwiththewntandtgfb1pathwaysinivfembryos AT peihe oxidativedamageinducedhyperactiveribosomebiogenesisparticipatesintumorigenesisofoffspringbycrossinteractingwiththewntandtgfb1pathwaysinivfembryos AT gaizhenru oxidativedamageinducedhyperactiveribosomebiogenesisparticipatesintumorigenesisofoffspringbycrossinteractingwiththewntandtgfb1pathwaysinivfembryos
_version_	1718371994727088128

Oxidative damage-induced hyperactive ribosome biogenesis participates in tumorigenesis of offspring by cross-interacting with the Wnt and TGF-β1 pathways in IVF embryos

Ejemplares similares