Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.

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Autores principales: Donghyun Ka, Hyejin Oh, Eunyoung Park, Jeong-Han Kim, Euiyoung Bae
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/f8b6653fb2e144b0a1e0302ac32e58fb
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