Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.

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Autores principales:	Donghyun Ka, Hyejin Oh, Eunyoung Park, Jeong-Han Kim, Euiyoung Bae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8b6653fb2e144b0a1e0302ac32e58fb
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spelling	oai:doaj.org-article:f8b6653fb2e144b0a1e0302ac32e58fb2021-12-02T17:51:27ZStructural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation10.1038/s41467-020-16703-w2041-1723https://doaj.org/article/f8b6653fb2e144b0a1e0302ac32e58fb2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16703-whttps://doaj.org/toc/2041-1723The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.Donghyun KaHyejin OhEunyoung ParkJeong-Han KimEuiyoung BaeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Donghyun Ka Hyejin Oh Eunyoung Park Jeong-Han Kim Euiyoung Bae Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
description	The Thoeris defense system is a recently discovered bacterial defense system that protects bacteria against phage infection and consists of the two genes thsA and thsB. Here, the authors present the crystal structures of Bacillus cereus ThsA and ThsB and show that ThsA is a NAD+ cleaving enzyme.
format	article
author	Donghyun Ka Hyejin Oh Eunyoung Park Jeong-Han Kim Euiyoung Bae
author_facet	Donghyun Ka Hyejin Oh Eunyoung Park Jeong-Han Kim Euiyoung Bae
author_sort	Donghyun Ka
title	Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
title_short	Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
title_full	Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
title_fullStr	Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
title_full_unstemmed	Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation
title_sort	structural and functional evidence of bacterial antiphage protection by thoeris defense system via nad+ degradation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/f8b6653fb2e144b0a1e0302ac32e58fb
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Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

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