Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions...

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Autores principales:	Oxana Nekrasova, Robert M. Harmon, Joshua A. Broussard, Jennifer L. Koetsier, Lisa M. Godsel, Gillian N. Fitz, Margaret L. Gardel, Kathleen J. Green
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8d863c46db64eadbafdd04712ce57e4
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spelling	oai:doaj.org-article:f8d863c46db64eadbafdd04712ce57e42021-12-02T15:34:20ZDesmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination10.1038/s41467-018-03414-62041-1723https://doaj.org/article/f8d863c46db64eadbafdd04712ce57e42018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03414-6https://doaj.org/toc/2041-1723The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin.Oxana NekrasovaRobert M. HarmonJoshua A. BroussardJennifer L. KoetsierLisa M. GodselGillian N. FitzMargaret L. GardelKathleen J. GreenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
description	The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by remodeling the actin cytoskeleton through interactions with the dynein light chain Tctex-1 and cortactin.
format	article
author	Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green
author_facet	Oxana Nekrasova Robert M. Harmon Joshua A. Broussard Jennifer L. Koetsier Lisa M. Godsel Gillian N. Fitz Margaret L. Gardel Kathleen J. Green
author_sort	Oxana Nekrasova
title	Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
title_short	Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
title_full	Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
title_fullStr	Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
title_full_unstemmed	Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
title_sort	desmosomal cadherin association with tctex-1 and cortactin-arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f8d863c46db64eadbafdd04712ce57e4
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Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

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