MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation

MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation

G protein-coupled receptors APLNR and CXCR4 are crucial for vascular development. Here, the authors show that these two signaling pathways communicate and that in response to blood flow APLNR signaling induces a decrease in CXCR4 expression via miR-139-5p, thereby restricting CXCR4 expression to the...

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Main Authors: Irinna Papangeli, Jongmin Kim, Inna Maier, Saejeong Park, Aram Lee, Yujung Kang, Keiichiro Tanaka, Omar F. Khan, Hyekyung Ju, Yoko Kojima, Kristy Red-Horse, Daniel G. Anderson, Arndt F. Siekmann, Hyung J. Chun
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/f8d99b3209af438b97ff65e526d3b632
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