Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p

Background & Aims: Immune-mediated induction of cytidine deaminase APOBEC3B (A3B) expression leads to HBV covalently closed circular DNA (cccDNA) decay. Here, we aimed to decipher the signalling pathway(s) and regulatory mechanism(s) involved in A3B induction and related HBV control. Methods...

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Auteurs principaux: Suzanne Faure-Dupuy, Tobias Riedl, Maude Rolland, Zoheir Hizir, Florian Reisinger, Katharina Neuhaus, Svenja Schuehle, Caroline Remouchamps, Nicolas Gillet, Maximilian Schönung, Mira Stadler, Jochen Wettengel, Romain Barnault, Romain Parent, Linda Christina Schuster, Rayan Farhat, Sandra Prokosch, Corinna Leuchtenberger, Rupert Öllinger, Thomas Engleitner, Karsten Rippe, Roland Rad, Kristian Unger, Darjus Tscharahganeh, Daniel B. Lipka, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwälder
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
APOBEC3B
Hepatitis B virus
NF-κB
miRNA
cccDNA
HBx
Diseases of the digestive system. Gastroenterology
RC799-869
Accès en ligne:https://doaj.org/article/f8e8591deea845fbbd851f975b52e574
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https://doaj.org/article/f8e8591deea845fbbd851f975b52e574

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