Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing...

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Autores principales: Juil Kim, Yuseok Moon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/f9005708ee3d454ab316aa47063bd30a
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