Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation

Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing...

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Autores principales: Juil Kim, Yuseok Moon
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/f9005708ee3d454ab316aa47063bd30a
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spelling oai:doaj.org-article:f9005708ee3d454ab316aa47063bd30a2021-12-02T17:02:05ZMucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation10.1038/s42003-021-02078-12399-3642https://doaj.org/article/f9005708ee3d454ab316aa47063bd30a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02078-1https://doaj.org/toc/2399-3642Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing insights into environmental stress-mediated signaling in CRC.Juil KimYuseok MoonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Juil Kim
Yuseok Moon
Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
description Kim and Moon find that the transcription factor PRDM1 is induced by ribosomal dysfunction in colorectal cancer (CRC) cells and associated with chemoresistance through a pathway involving IGF signaling. The authors further suggest PRDM1 promotes cancer cell stemness and survival, altogether providing insights into environmental stress-mediated signaling in CRC.
format article
author Juil Kim
Yuseok Moon
author_facet Juil Kim
Yuseok Moon
author_sort Juil Kim
title Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
title_short Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
title_full Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
title_fullStr Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
title_full_unstemmed Mucosal ribosomal stress-induced PRDM1 promotes chemoresistance via stemness regulation
title_sort mucosal ribosomal stress-induced prdm1 promotes chemoresistance via stemness regulation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/f9005708ee3d454ab316aa47063bd30a
work_keys_str_mv AT juilkim mucosalribosomalstressinducedprdm1promoteschemoresistanceviastemnessregulation
AT yuseokmoon mucosalribosomalstressinducedprdm1promoteschemoresistanceviastemnessregulation
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