Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy

The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of fatty acid oxidation in diabetic kidneys.

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Autores principales:	Swayam Prakash Srivastava, Han Zhou, Ocean Setia, Bing Liu, Keizo Kanasaki, Daisuke Koya, Alan Dardik, Carlos Fernandez-Hernando, Julie Goodwin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f93663ef9d3e4bd39f4587ef786d5886
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spelling	oai:doaj.org-article:f93663ef9d3e4bd39f4587ef786d58862021-12-02T16:45:10ZLoss of endothelial glucocorticoid receptor accelerates diabetic nephropathy10.1038/s41467-021-22617-y2041-1723https://doaj.org/article/f93663ef9d3e4bd39f4587ef786d58862021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22617-yhttps://doaj.org/toc/2041-1723The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of fatty acid oxidation in diabetic kidneys.Swayam Prakash SrivastavaHan ZhouOcean SetiaBing LiuKeizo KanasakiDaisuke KoyaAlan DardikCarlos Fernandez-HernandoJulie GoodwinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Swayam Prakash Srivastava Han Zhou Ocean Setia Bing Liu Keizo Kanasaki Daisuke Koya Alan Dardik Carlos Fernandez-Hernando Julie Goodwin Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
description	The endothelial glucocorticoid receptor plays a key role in the regulation of many diseases, including diabetes. Loss of this receptor results in accelerated renal fibrosis, a heightened inflammatory milieu, augmented Wnt signaling and suppression of fatty acid oxidation in diabetic kidneys.
format	article
author	Swayam Prakash Srivastava Han Zhou Ocean Setia Bing Liu Keizo Kanasaki Daisuke Koya Alan Dardik Carlos Fernandez-Hernando Julie Goodwin
author_facet	Swayam Prakash Srivastava Han Zhou Ocean Setia Bing Liu Keizo Kanasaki Daisuke Koya Alan Dardik Carlos Fernandez-Hernando Julie Goodwin
author_sort	Swayam Prakash Srivastava
title	Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
title_short	Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
title_full	Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
title_fullStr	Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
title_full_unstemmed	Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
title_sort	loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f93663ef9d3e4bd39f4587ef786d5886
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Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy

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