Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration by triggering IN proteasome-mediated degradation.

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Autores principales:	Hashim Ali, Miguel Mano, Luca Braga, Asma Naseem, Bruna Marini, Diem My Vu, Chiara Collesi, Germana Meroni, Marina Lusic, Mauro Giacca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f93cc3e0668a4faa96dbc3035b454cec
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spelling	oai:doaj.org-article:f93cc3e0668a4faa96dbc3035b454cec2021-12-02T17:01:31ZCellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation10.1038/s41467-019-08810-02041-1723https://doaj.org/article/f93cc3e0668a4faa96dbc3035b454cec2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08810-0https://doaj.org/toc/2041-1723HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration by triggering IN proteasome-mediated degradation.Hashim AliMiguel ManoLuca BragaAsma NaseemBruna MariniDiem My VuChiara CollesiGermana MeroniMarina LusicMauro GiaccaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hashim Ali Miguel Mano Luca Braga Asma Naseem Bruna Marini Diem My Vu Chiara Collesi Germana Meroni Marina Lusic Mauro Giacca Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
description	HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration by triggering IN proteasome-mediated degradation.
format	article
author	Hashim Ali Miguel Mano Luca Braga Asma Naseem Bruna Marini Diem My Vu Chiara Collesi Germana Meroni Marina Lusic Mauro Giacca
author_facet	Hashim Ali Miguel Mano Luca Braga Asma Naseem Bruna Marini Diem My Vu Chiara Collesi Germana Meroni Marina Lusic Mauro Giacca
author_sort	Hashim Ali
title	Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
title_short	Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
title_full	Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
title_fullStr	Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
title_full_unstemmed	Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
title_sort	cellular trim33 restrains hiv-1 infection by targeting viral integrase for proteasomal degradation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f93cc3e0668a4faa96dbc3035b454cec
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Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation

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