Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jonathan Richard, Dung N. Nguyen, William D. Tolbert, Romain Gasser, Shilei Ding, Dani Vézina, Shang Yu Gong, Jérémie Prévost, Gabrielle Gendron-Lepage, Halima Medjahed, Suneetha Gottumukkala, Andrés Finzi, Marzena Pazgier
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Acceso en línea:https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d2
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!