Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of...

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Autores principales:	Jonathan Richard, Dung N. Nguyen, William D. Tolbert, Romain Gasser, Shilei Ding, Dani Vézina, Shang Yu Gong, Jérémie Prévost, Gabrielle Gendron-Lepage, Halima Medjahed, Suneetha Gottumukkala, Andrés Finzi, Marzena Pazgier
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d2
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spelling	oai:doaj.org-article:f9c7bceebbc243d6b3de645a7dec77d22021-11-03T21:52:35ZAcross Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells2150-751110.1128/mBio.01405-21https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d22021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01405-21https://doaj.org/toc/2150-7511 Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of CD4 is downregulated. Here, we have developed new antibody fusion molecules in which domains 1 and 2 of soluble human CD4 are linked with monoclonal antibodies of either the CoRBS or cluster A specificity.Jonathan RichardDung N. NguyenWilliam D. TolbertRomain GasserShilei DingDani VézinaShang Yu GongJérémie PrévostGabrielle Gendron-LepageHalima MedjahedSuneetha GottumukkalaAndrés FinziMarzena PazgierAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jonathan Richard Dung N. Nguyen William D. Tolbert Romain Gasser Shilei Ding Dani Vézina Shang Yu Gong Jérémie Prévost Gabrielle Gendron-Lepage Halima Medjahed Suneetha Gottumukkala Andrés Finzi Marzena Pazgier Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
description	Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of CD4 is downregulated. Here, we have developed new antibody fusion molecules in which domains 1 and 2 of soluble human CD4 are linked with monoclonal antibodies of either the CoRBS or cluster A specificity.
format	article
author	Jonathan Richard Dung N. Nguyen William D. Tolbert Romain Gasser Shilei Ding Dani Vézina Shang Yu Gong Jérémie Prévost Gabrielle Gendron-Lepage Halima Medjahed Suneetha Gottumukkala Andrés Finzi Marzena Pazgier
author_facet	Jonathan Richard Dung N. Nguyen William D. Tolbert Romain Gasser Shilei Ding Dani Vézina Shang Yu Gong Jérémie Prévost Gabrielle Gendron-Lepage Halima Medjahed Suneetha Gottumukkala Andrés Finzi Marzena Pazgier
author_sort	Jonathan Richard
title	Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
title_short	Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
title_full	Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
title_fullStr	Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
title_full_unstemmed	Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells
title_sort	across functional boundaries: making nonneutralizing antibodies to neutralize hiv-1 and mediate fc-mediated effector killing of infected cells
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d2
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Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

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