Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

Across Functional Boundaries: Making Nonneutralizing Antibodies To Neutralize HIV-1 and Mediate Fc-Mediated Effector Killing of Infected Cells

Highly conserved epitopes within the coreceptor binding site (CoRBS) and constant region 1 and 2 (C1-C2 or cluster A) are only available for antibody recognition after the HIV-1 Env trimer binds host cell CD4; therefore, they are not accessible on virions and infected cells, where the expression of...

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Main Authors: Jonathan Richard, Dung N. Nguyen, William D. Tolbert, Romain Gasser, Shilei Ding, Dani Vézina, Shang Yu Gong, Jérémie Prévost, Gabrielle Gendron-Lepage, Halima Medjahed, Suneetha Gottumukkala, Andrés Finzi, Marzena Pazgier
Format: article
Language:EN
Published: American Society for Microbiology 2021
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/f9c7bceebbc243d6b3de645a7dec77d2
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