Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE<sub>2</sub> Productions and Nitric Oxide in Murine RAW 264.7 Macrophages

Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE<sub>2</sub> Productions and Nitric Oxide in Murine RAW 264.7 Macrophages

A series of thirteen triarylpyrazole analogs were investigated as inhibitors of lipopolysaccharide (LPS)-induced prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) and nitric oxide (NO) production in RAW 264.7 macrophages. The target compounds <b>1a</b>–<b>m</...

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Bibliographic Details
Main Authors: Mahmoud M. Gamal El-Din, Mohammed I. El-Gamal, Young-Do Kwon, Su-Yeon Kim, Hee-Soo Han, Sang-Eun Park, Chang-Hyun Oh, Kyung-Tae Lee, Hee-Kwon Kim
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
amide
anti-inflammatory
COX-2
iNOS
NO
PGE<sub>2</sub>
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/f9d0f03beb1344b18df4f2d77a158151
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https://doaj.org/article/f9d0f03beb1344b18df4f2d77a158151

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