Impact of Airway Inflammation on the Efficacy of CFTR Modulators

Defective CFTR biogenesis and activity in cystic fibrosis airways leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. Most cystic fibrosis patients have at least one copy of the F508del CFTR mutation, which results in a protein reta...

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Autores principales: Carla M. P. Ribeiro, Martina Gentzsch
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/f9f44a2056ee478cb0717cd119c96584
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