The Effect of a Single Dose of Thiamine on Oxygen Consumption in Patients Requiring Mechanical Ventilation for Acute Illness: A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial

IMPORTANCE:. Lower oxygen consumption is associated with worse survival in septic shock and in other forms of critical illness. No treatment that increases oxygen extraction, a key determinant of oxygen consumption, has been found. Thiamine is required for aerobic metabolism, and deficiency is commo...

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Main Authors: Katherine M. Berg, MD, Anne V. Grossestreuer, PhD, Lars W. Andersen, MD, PhD, Xiaowen Liu, PhD, Michael W. Donnino, MD
Format: article
Language:EN
Published: Wolters Kluwer 2021
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Online Access:https://doaj.org/article/fa05ca4a171e4192b6f9f1eab60c0245
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