PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.

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Auteurs principaux:	Asma Boukhalfa, Anna Chiara Nascimbeni, Damien Ramel, Nicolas Dupont, Emilio Hirsch, Stephanie Gayral, Muriel Laffargue, Patrice Codogno, Etienne Morel
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/fa222810d04142ff9c1ee0a2e1dc9f96
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spelling	oai:doaj.org-article:fa222810d04142ff9c1ee0a2e1dc9f962021-12-02T17:31:09ZPI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress10.1038/s41467-019-14086-12041-1723https://doaj.org/article/fa222810d04142ff9c1ee0a2e1dc9f962020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14086-1https://doaj.org/toc/2041-1723The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.Asma BoukhalfaAnna Chiara NascimbeniDamien RamelNicolas DupontEmilio HirschStephanie GayralMuriel LaffarguePatrice CodognoEtienne MorelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
description	The primary cilium is required for the autophagic response to shear stress. Here, the authors show that PI3KC2α has a role in ciliogenesis and promotes local PI3P production upon shear stress to induce autophagy that is distinct from VPS34-driven starvation-induced autophagy.
format	article
author	Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel
author_facet	Asma Boukhalfa Anna Chiara Nascimbeni Damien Ramel Nicolas Dupont Emilio Hirsch Stephanie Gayral Muriel Laffargue Patrice Codogno Etienne Morel
author_sort	Asma Boukhalfa
title	PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
title_short	PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
title_full	PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
title_fullStr	PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
title_full_unstemmed	PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress
title_sort	pi3kc2α-dependent and vps34-independent generation of pi3p controls primary cilium-mediated autophagy in response to shear stress
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fa222810d04142ff9c1ee0a2e1dc9f96
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PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

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