Network-based prediction of drug combinations

Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods of the disease module in the human interactome.

Guardado en:

Detalles Bibliográficos
Autores principales:	Feixiong Cheng, István A. Kovács, Albert-László Barabási
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa2350977aa946a497b6fc542fe19dad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:fa2350977aa946a497b6fc542fe19dad
record_format	dspace
spelling	oai:doaj.org-article:fa2350977aa946a497b6fc542fe19dad2021-12-02T17:31:36ZNetwork-based prediction of drug combinations10.1038/s41467-019-09186-x2041-1723https://doaj.org/article/fa2350977aa946a497b6fc542fe19dad2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09186-xhttps://doaj.org/toc/2041-1723Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods of the disease module in the human interactome.Feixiong ChengIstván A. KovácsAlbert-László BarabásiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feixiong Cheng István A. Kovács Albert-László Barabási Network-based prediction of drug combinations
description	Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods of the disease module in the human interactome.
format	article
author	Feixiong Cheng István A. Kovács Albert-László Barabási
author_facet	Feixiong Cheng István A. Kovács Albert-László Barabási
author_sort	Feixiong Cheng
title	Network-based prediction of drug combinations
title_short	Network-based prediction of drug combinations
title_full	Network-based prediction of drug combinations
title_fullStr	Network-based prediction of drug combinations
title_full_unstemmed	Network-based prediction of drug combinations
title_sort	network-based prediction of drug combinations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/fa2350977aa946a497b6fc542fe19dad
work_keys_str_mv	AT feixiongcheng networkbasedpredictionofdrugcombinations AT istvanakovacs networkbasedpredictionofdrugcombinations AT albertlaszlobarabasi networkbasedpredictionofdrugcombinations
_version_	1718380591645196288

Network-based prediction of drug combinations

Ejemplares similares