Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ke...

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Autores principales:	Zhaodong Li, Rubén O. Torres-Ochoa, Qian Wang, Jieping Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa2abf7032de466aab33b7098f4cbaf9
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spelling	oai:doaj.org-article:fa2abf7032de466aab33b7098f4cbaf92021-12-02T15:39:17ZFunctionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes10.1038/s41467-020-14292-22041-1723https://doaj.org/article/fa2abf7032de466aab33b7098f4cbaf92020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14292-2https://doaj.org/toc/2041-1723Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ketones, respectively.Zhaodong LiRubén O. Torres-OchoaQian WangJieping ZhuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaodong Li Rubén O. Torres-Ochoa Qian Wang Jieping Zhu Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
description	Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ketones, respectively.
format	article
author	Zhaodong Li Rubén O. Torres-Ochoa Qian Wang Jieping Zhu
author_facet	Zhaodong Li Rubén O. Torres-Ochoa Qian Wang Jieping Zhu
author_sort	Zhaodong Li
title	Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
title_short	Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
title_full	Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
title_fullStr	Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
title_full_unstemmed	Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes
title_sort	functionalization of remote c(sp3)-h bonds enabled by copper-catalyzed coupling of o-acyloximes with terminal alkynes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fa2abf7032de466aab33b7098f4cbaf9
work_keys_str_mv	AT zhaodongli functionalizationofremotecsp3hbondsenabledbycoppercatalyzedcouplingofoacyloximeswithterminalalkynes AT rubenotorresochoa functionalizationofremotecsp3hbondsenabledbycoppercatalyzedcouplingofoacyloximeswithterminalalkynes AT qianwang functionalizationofremotecsp3hbondsenabledbycoppercatalyzedcouplingofoacyloximeswithterminalalkynes AT jiepingzhu functionalizationofremotecsp3hbondsenabledbycoppercatalyzedcouplingofoacyloximeswithterminalalkynes
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Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

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