Functionalization of remote C(sp3)-H bonds enabled by copper-catalyzed coupling of O-acyloximes with terminal alkynes

Sonogashira cross-coupling is a powerful strategy to prepare functionalized internal alkynes. Here, the authors report a domino sequence for the generation of γ-/δ-alkynyl nitriles and γ-alkynyl ketones from the coupling of terminal alkynes with O-acyloximes derived from cycloalkanones and acylic ke...

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Bibliographic Details
Main Authors: Zhaodong Li, Rubén O. Torres-Ochoa, Qian Wang, Jieping Zhu
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/fa2abf7032de466aab33b7098f4cbaf9
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