Catalytic enantioselective reductive domino alkyl arylation of acrylates via nickel/photoredox catalysis

Enantioenriched α-aryl propionic acids are an important class of nonsteroidal anti-inflammatory medications. Here the authors use a visible-light-promoted photoredox/nickel catalyzed method to form such compunds via a three-component alkyl arylation of acrylates.

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Autores principales: Pengcheng Qian, Haixing Guan, Yan-En Wang, Qianqian Lu, Fan Zhang, Dan Xiong, Patrick J. Walsh, Jianyou Mao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fa45e986c72b46ca9096bd04bd38fc39
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