THE ROLE OF THERAPEUTIC DRUG MONITORING OF INTRAVENOUS BUSULFAN FOR PREVENTION OF SINUSOIDAL OBSTRUCTION SYNDROME IN CHILDREN

Objective: Busulfan is a widely used alkylating drug for conditioning of hematopoietic stem cell transplantation (HSCT). Higher exposure of Bu is associated with toxicity and (sinusoidal obstruction syndrome) SOS, whereas lower exposure is associated with graft failure or relapse risk. Therapeutic d...

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Autores principales: Dilek GURLEK GOKCEBAY, ÖzlemArman Bilir, İkbal Ok Bozkaya, Namık Yaşar Özbek, Seda Şahin
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/fa589eab85c64341a65175faae1192f6
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