Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease

Abstract More than one thousand knotted protein structures have been identified so far, but the functional roles of these knots remain elusive. It has been postulated that backbone entanglement may provide additional mechanostability. Here, we employed a bacterial proteasome, ClpXP, to mechanically...

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Auteurs principaux: Manoj Kumar Sriramoju, Yen Chen, Yun-Tzai Cloud Lee, Shang-Te Danny Hsu
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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R
Q
Accès en ligne:https://doaj.org/article/fa864d0cc6a64dd7a10217775b02ea30
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