Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response

Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response

Protein O-GlcNAcylation is involved in regulating gene expression and maintaining cellular homeostasis. Here, the authors develop a chemical reporter-based strategy for the proteomic profiling and genome-wide mapping of genotoxic stress-induced O-GlcNAcylated chromatin-associated proteins.

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Detalles Bibliográficos
Autores principales: Yubo Liu, Qiushi Chen, Nana Zhang, Keren Zhang, Tongyi Dou, Yu Cao, Yimin Liu, Kun Li, Xinya Hao, Xueqin Xie, Wenli Li, Yan Ren, Jianing Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/fa8b1551ee7240468ce7c0368d1c74e8
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https://doaj.org/article/fa8b1551ee7240468ce7c0368d1c74e8

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