Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response

Protein O-GlcNAcylation is involved in regulating gene expression and maintaining cellular homeostasis. Here, the authors develop a chemical reporter-based strategy for the proteomic profiling and genome-wide mapping of genotoxic stress-induced O-GlcNAcylated chromatin-associated proteins.

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Autores principales:	Yubo Liu, Qiushi Chen, Nana Zhang, Keren Zhang, Tongyi Dou, Yu Cao, Yimin Liu, Kun Li, Xinya Hao, Xueqin Xie, Wenli Li, Yan Ren, Jianing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fa8b1551ee7240468ce7c0368d1c74e8
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spelling	oai:doaj.org-article:fa8b1551ee7240468ce7c0368d1c74e82021-12-02T14:41:12ZProteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response10.1038/s41467-020-19579-y2041-1723https://doaj.org/article/fa8b1551ee7240468ce7c0368d1c74e82020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19579-yhttps://doaj.org/toc/2041-1723Protein O-GlcNAcylation is involved in regulating gene expression and maintaining cellular homeostasis. Here, the authors develop a chemical reporter-based strategy for the proteomic profiling and genome-wide mapping of genotoxic stress-induced O-GlcNAcylated chromatin-associated proteins.Yubo LiuQiushi ChenNana ZhangKeren ZhangTongyi DouYu CaoYimin LiuKun LiXinya HaoXueqin XieWenli LiYan RenJianing ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yubo Liu Qiushi Chen Nana Zhang Keren Zhang Tongyi Dou Yu Cao Yimin Liu Kun Li Xinya Hao Xueqin Xie Wenli Li Yan Ren Jianing Zhang Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
description	Protein O-GlcNAcylation is involved in regulating gene expression and maintaining cellular homeostasis. Here, the authors develop a chemical reporter-based strategy for the proteomic profiling and genome-wide mapping of genotoxic stress-induced O-GlcNAcylated chromatin-associated proteins.
format	article
author	Yubo Liu Qiushi Chen Nana Zhang Keren Zhang Tongyi Dou Yu Cao Yimin Liu Kun Li Xinya Hao Xueqin Xie Wenli Li Yan Ren Jianing Zhang
author_facet	Yubo Liu Qiushi Chen Nana Zhang Keren Zhang Tongyi Dou Yu Cao Yimin Liu Kun Li Xinya Hao Xueqin Xie Wenli Li Yan Ren Jianing Zhang
author_sort	Yubo Liu
title	Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
title_short	Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
title_full	Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
title_fullStr	Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
title_full_unstemmed	Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response
title_sort	proteomic profiling and genome-wide mapping of o-glcnac chromatin-associated proteins reveal an o-glcnac-regulated genotoxic stress response
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/fa8b1551ee7240468ce7c0368d1c74e8
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Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response

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