CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation

CRISPR/Cas9 small promoter deletion in H19 lncRNA is associated with altered cell morphology and proliferation

Abstract The imprinted H19 long non-coding RNA, a knowing oncofetal gene, presents a controversial role during the carcinogenesis process since its tumor suppressor or oncogenic activity is not completely elucidated. Since H19 lncRNA is involved in many biological pathways related to tumorigenesis,...

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Autores principales: Renan da Silva Santos, Daniel Pascoalino Pinheiro, Louhanna Pinheiro Rodrigues Teixeira, Sarah Leyenne Alves Sales, Maria Claudia dos Santos Luciano, Mayara Magna de Lima Melo, Ronald Feitosa Pinheiro, Kaio César Simiano Tavares, Gilvan Pessoa Furtado, Claudia Pessoa, Cristiana Libardi Miranda Furtado
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fa96d963cb0e487eafea13981072274b
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