Stimulus design for model selection and validation in cell signaling.

Mechanism-based chemical kinetic models are increasingly being used to describe biological signaling. Such models serve to encapsulate current understanding of pathways and to enable insight into complex biological processes. One challenge in model development is that, with limited experimental data...

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Bibliographic Details
Main Authors: Joshua F Apgar, Jared E Toettcher, Drew Endy, Forest M White, Bruce Tidor
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2008
Subjects:
Online Access:https://doaj.org/article/fab8e059031a4b60914c1ca14447329d
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