Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

Currently there are no therapeutics for long lasting central nervous system injuries, that can address the complex injury cascade that develops over years. Here the authors report biomaterial scaffolds that release 17β-estradiol (E2) at nanomolar concentrations over the course of 1–10 years via slow...

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Autores principales:	Anthony R. D’Amato, Devan L. Puhl, Samuel A. T. Ellman, Bailey Balouch, Ryan J. Gilbert, Edmund F. Palermo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/facc268ea7b44527b13cd95f6a38119e
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spelling	oai:doaj.org-article:facc268ea7b44527b13cd95f6a38119e2021-12-02T14:35:50ZVastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection10.1038/s41467-019-12835-w2041-1723https://doaj.org/article/facc268ea7b44527b13cd95f6a38119e2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12835-whttps://doaj.org/toc/2041-1723Currently there are no therapeutics for long lasting central nervous system injuries, that can address the complex injury cascade that develops over years. Here the authors report biomaterial scaffolds that release 17β-estradiol (E2) at nanomolar concentrations over the course of 1–10 years via slow hydrolysis in vitro.Anthony R. D’AmatoDevan L. PuhlSamuel A. T. EllmanBailey BalouchRyan J. GilbertEdmund F. PalermoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anthony R. D’Amato Devan L. Puhl Samuel A. T. Ellman Bailey Balouch Ryan J. Gilbert Edmund F. Palermo Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
description	Currently there are no therapeutics for long lasting central nervous system injuries, that can address the complex injury cascade that develops over years. Here the authors report biomaterial scaffolds that release 17β-estradiol (E2) at nanomolar concentrations over the course of 1–10 years via slow hydrolysis in vitro.
format	article
author	Anthony R. D’Amato Devan L. Puhl Samuel A. T. Ellman Bailey Balouch Ryan J. Gilbert Edmund F. Palermo
author_facet	Anthony R. D’Amato Devan L. Puhl Samuel A. T. Ellman Bailey Balouch Ryan J. Gilbert Edmund F. Palermo
author_sort	Anthony R. D’Amato
title	Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
title_short	Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
title_full	Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
title_fullStr	Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
title_full_unstemmed	Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
title_sort	vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/facc268ea7b44527b13cd95f6a38119e
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Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection

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