Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation

Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation

Abstract Bmp plays an important role in cardiomyocyte differentiation, but the function of Smad4 in Bmp signaling remains elusive. Here, we show that disruption of the Smad4 gene in cardiac progenitors expressing Sfrp5 led to embryonic lethality with hypoplastic heart formation. Although the express...

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Autores principales: Wenyu Hu, Anqi Dong, Kohei Karasaki, Shota Sogabe, Daiki Okamoto, Masato Saigo, Mari Ishida, Masao Yoshizumi, Hiroki Kokubo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/facdf754252742c58ba07118dc45ac9e
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