A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells

The majority of enterovirus proteins are encoded as polyprotein in one open reading frame. Here, Guo et al. characterize a second open reading frame in human enteroviruses and show that it is important for viral particle release, particularly in epithelial cells, and that it affects mortality in a m...

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Autores principales: Haoran Guo, Yan Li, Guanchen Liu, Yunhe Jiang, Siyu Shen, Ran Bi, Honglan Huang, Tong Cheng, Chunxi Wang, Wei Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fad891a133ec48afbf15f674a3fed595
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