A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells

A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells

The majority of enterovirus proteins are encoded as polyprotein in one open reading frame. Here, Guo et al. characterize a second open reading frame in human enteroviruses and show that it is important for viral particle release, particularly in epithelial cells, and that it affects mortality in a m...

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Autores principales: Haoran Guo, Yan Li, Guanchen Liu, Yunhe Jiang, Siyu Shen, Ran Bi, Honglan Huang, Tong Cheng, Chunxi Wang, Wei Wei
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fad891a133ec48afbf15f674a3fed595
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spelling oai:doaj.org-article:fad891a133ec48afbf15f674a3fed5952021-12-02T16:57:45ZA second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells10.1038/s41467-019-12040-92041-1723https://doaj.org/article/fad891a133ec48afbf15f674a3fed5952019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12040-9https://doaj.org/toc/2041-1723The majority of enterovirus proteins are encoded as polyprotein in one open reading frame. Here, Guo et al. characterize a second open reading frame in human enteroviruses and show that it is important for viral particle release, particularly in epithelial cells, and that it affects mortality in a mouse model.Haoran GuoYan LiGuanchen LiuYunhe JiangSiyu ShenRan BiHonglan HuangTong ChengChunxi WangWei WeiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haoran Guo
Yan Li
Guanchen Liu
Yunhe Jiang
Siyu Shen
Ran Bi
Honglan Huang
Tong Cheng
Chunxi Wang
Wei Wei
A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
description The majority of enterovirus proteins are encoded as polyprotein in one open reading frame. Here, Guo et al. characterize a second open reading frame in human enteroviruses and show that it is important for viral particle release, particularly in epithelial cells, and that it affects mortality in a mouse model.
format article
author Haoran Guo
Yan Li
Guanchen Liu
Yunhe Jiang
Siyu Shen
Ran Bi
Honglan Huang
Tong Cheng
Chunxi Wang
Wei Wei
author_facet Haoran Guo
Yan Li
Guanchen Liu
Yunhe Jiang
Siyu Shen
Ran Bi
Honglan Huang
Tong Cheng
Chunxi Wang
Wei Wei
author_sort Haoran Guo
title A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
title_short A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
title_full A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
title_fullStr A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
title_full_unstemmed A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
title_sort second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/fad891a133ec48afbf15f674a3fed595
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