Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness.
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Nature Portfolio
2019
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oai:doaj.org-article:faee146ac94c4c129948d57be9f339e02021-12-02T17:01:34ZFunctional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening10.1038/s41467-019-09940-12041-1723https://doaj.org/article/faee146ac94c4c129948d57be9f339e02019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09940-1https://doaj.org/toc/2041-1723Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness.Gabriele PiccoElisabeth D. ChenLuz Garcia AlonsoFiona M. BehanEmanuel GonçalvesGraham BignellAngela MatchanBeiyuan FuRuby BanerjeeElizabeth AndersonAdam ButlerCyril H. BenesUltan McDermottDavid DowFrancesco IorioEuan StronachFengtang YangKosuke YusaJulio Saez-RodriguezMathew J. GarnettNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gabriele Picco Elisabeth D. Chen Luz Garcia Alonso Fiona M. Behan Emanuel Gonçalves Graham Bignell Angela Matchan Beiyuan Fu Ruby Banerjee Elizabeth Anderson Adam Butler Cyril H. Benes Ultan McDermott David Dow Francesco Iorio Euan Stronach Fengtang Yang Kosuke Yusa Julio Saez-Rodriguez Mathew J. Garnett Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| description |
Gene fusions are observed in many cancers but their link to tumour fitness is largely unknown. Here, transcriptomic analysis combined with pharmacological and CRISPR-Cas9 screening of cancer cell lines was used to evaluate the functional linkage between fusions and tumour fitness. |
| format |
article |
| author |
Gabriele Picco Elisabeth D. Chen Luz Garcia Alonso Fiona M. Behan Emanuel Gonçalves Graham Bignell Angela Matchan Beiyuan Fu Ruby Banerjee Elizabeth Anderson Adam Butler Cyril H. Benes Ultan McDermott David Dow Francesco Iorio Euan Stronach Fengtang Yang Kosuke Yusa Julio Saez-Rodriguez Mathew J. Garnett |
| author_facet |
Gabriele Picco Elisabeth D. Chen Luz Garcia Alonso Fiona M. Behan Emanuel Gonçalves Graham Bignell Angela Matchan Beiyuan Fu Ruby Banerjee Elizabeth Anderson Adam Butler Cyril H. Benes Ultan McDermott David Dow Francesco Iorio Euan Stronach Fengtang Yang Kosuke Yusa Julio Saez-Rodriguez Mathew J. Garnett |
| author_sort |
Gabriele Picco |
| title |
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| title_short |
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| title_full |
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| title_fullStr |
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| title_full_unstemmed |
Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening |
| title_sort |
functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and crispr-cas9 screening |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/faee146ac94c4c129948d57be9f339e0 |
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