Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.

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Autores principales: Naoki Yoneda, Yuki Fujii, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/fb183a434d4a45feb28b7621af19abbf
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