Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.

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Autores principales:	Naoki Yoneda, Yuki Fujii, Akira Matsumoto, Keisuke Asano, Seijiro Matsubara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb183a434d4a45feb28b7621af19abbf
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spelling	oai:doaj.org-article:fb183a434d4a45feb28b7621af19abbf2021-12-02T14:42:22ZOrganocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins10.1038/s41467-017-01099-x2041-1723https://doaj.org/article/fb183a434d4a45feb28b7621af19abbf2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01099-xhttps://doaj.org/toc/2041-1723Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.Naoki YonedaYuki FujiiAkira MatsumotoKeisuke AsanoSeijiro MatsubaraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoki Yoneda Yuki Fujii Akira Matsumoto Keisuke Asano Seijiro Matsubara Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
description	Enantioselective synthesis of six-membered oxacycles with multiple stereogenic centres is essential for the discovery of new therapeutic agents. Here the authors show organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans.
format	article
author	Naoki Yoneda Yuki Fujii Akira Matsumoto Keisuke Asano Seijiro Matsubara
author_facet	Naoki Yoneda Yuki Fujii Akira Matsumoto Keisuke Asano Seijiro Matsubara
author_sort	Naoki Yoneda
title	Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
title_short	Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
title_full	Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
title_fullStr	Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
title_full_unstemmed	Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
title_sort	organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb183a434d4a45feb28b7621af19abbf
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Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins

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