Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants

Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants

Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.

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Bibliographic Details
Main Authors: Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern, Julius Beer, Hendrik Luxenburger, Jakob Ankerhold, Valeria Falcone, Janine Kemming, Maike Hofmann, Robert Thimme, Christoph Neumann-Haefelin, Svenja Ulferts, Robert Grosse, Daniel Hornuss, Yakup Tanriver, Siegbert Rieg, Dirk Wagner, Daniela Huzly, Martin Schwemmle, Marcus Panning, Georg Kochs
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee
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https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee

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