Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.
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Nature Portfolio
2021
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oai:doaj.org-article:fb1ea91842db4a2381c73359e44031ee2021-11-08T11:07:16ZWithin-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants10.1038/s41467-021-26602-32041-1723https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26602-3https://doaj.org/toc/2041-1723Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization.Sebastian WeigangJonas FuchsGert ZimmerDaniel SchnepfLisa KernJulius BeerHendrik LuxenburgerJakob AnkerholdValeria FalconeJanine KemmingMaike HofmannRobert ThimmeChristoph Neumann-HaefelinSvenja UlfertsRobert GrosseDaniel HornussYakup TanriverSiegbert RiegDirk WagnerDaniela HuzlyMartin SchwemmleMarcus PanningGeorg KochsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sebastian Weigang Jonas Fuchs Gert Zimmer Daniel Schnepf Lisa Kern Julius Beer Hendrik Luxenburger Jakob Ankerhold Valeria Falcone Janine Kemming Maike Hofmann Robert Thimme Christoph Neumann-Haefelin Svenja Ulferts Robert Grosse Daniel Hornuss Yakup Tanriver Siegbert Rieg Dirk Wagner Daniela Huzly Martin Schwemmle Marcus Panning Georg Kochs Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| description |
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization. |
| format |
article |
| author |
Sebastian Weigang Jonas Fuchs Gert Zimmer Daniel Schnepf Lisa Kern Julius Beer Hendrik Luxenburger Jakob Ankerhold Valeria Falcone Janine Kemming Maike Hofmann Robert Thimme Christoph Neumann-Haefelin Svenja Ulferts Robert Grosse Daniel Hornuss Yakup Tanriver Siegbert Rieg Dirk Wagner Daniela Huzly Martin Schwemmle Marcus Panning Georg Kochs |
| author_facet |
Sebastian Weigang Jonas Fuchs Gert Zimmer Daniel Schnepf Lisa Kern Julius Beer Hendrik Luxenburger Jakob Ankerhold Valeria Falcone Janine Kemming Maike Hofmann Robert Thimme Christoph Neumann-Haefelin Svenja Ulferts Robert Grosse Daniel Hornuss Yakup Tanriver Siegbert Rieg Dirk Wagner Daniela Huzly Martin Schwemmle Marcus Panning Georg Kochs |
| author_sort |
Sebastian Weigang |
| title |
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| title_short |
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| title_full |
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| title_fullStr |
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| title_full_unstemmed |
Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| title_sort |
within-host evolution of sars-cov-2 in an immunosuppressed covid-19 patient as a source of immune escape variants |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/fb1ea91842db4a2381c73359e44031ee |
| work_keys_str_mv |
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