Mistranslation can enhance fitness through purging of deleterious mutations

Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutati...

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Autores principales:	Sinisa Bratulic, Macarena Toll-Riera, Andreas Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb502bf724b9452c9364e777945360ab
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spelling	oai:doaj.org-article:fb502bf724b9452c9364e777945360ab2021-12-02T14:42:23ZMistranslation can enhance fitness through purging of deleterious mutations10.1038/ncomms154102041-1723https://doaj.org/article/fb502bf724b9452c9364e777945360ab2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15410https://doaj.org/toc/2041-1723Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations.Sinisa BratulicMacarena Toll-RieraAndreas WagnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sinisa Bratulic Macarena Toll-Riera Andreas Wagner Mistranslation can enhance fitness through purging of deleterious mutations
description	Mistranslation results in amino acid changes in proteins known as phenotypic mutations and these occur at a much higher rate than DNA mutations. Here, the authors show that mistranslation can increase the response to directional selection by exacerbating the fitness effects of deleterious DNA mutations.
format	article
author	Sinisa Bratulic Macarena Toll-Riera Andreas Wagner
author_facet	Sinisa Bratulic Macarena Toll-Riera Andreas Wagner
author_sort	Sinisa Bratulic
title	Mistranslation can enhance fitness through purging of deleterious mutations
title_short	Mistranslation can enhance fitness through purging of deleterious mutations
title_full	Mistranslation can enhance fitness through purging of deleterious mutations
title_fullStr	Mistranslation can enhance fitness through purging of deleterious mutations
title_full_unstemmed	Mistranslation can enhance fitness through purging of deleterious mutations
title_sort	mistranslation can enhance fitness through purging of deleterious mutations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fb502bf724b9452c9364e777945360ab
work_keys_str_mv	AT sinisabratulic mistranslationcanenhancefitnessthroughpurgingofdeleteriousmutations AT macarenatollriera mistranslationcanenhancefitnessthroughpurgingofdeleteriousmutations AT andreaswagner mistranslationcanenhancefitnessthroughpurgingofdeleteriousmutations
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Mistranslation can enhance fitness through purging of deleterious mutations

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