Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.

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Autores principales: G. O. Sipe, R. L. Lowery, M-È Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/fb70b318d73d4bd78b815fa26df1f66e
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