Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.

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Autores principales:	G. O. Sipe, R. L. Lowery, M-È Tremblay, E. A. Kelly, C. E. Lamantia, A. K. Majewska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fb70b318d73d4bd78b815fa26df1f66e
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spelling	oai:doaj.org-article:fb70b318d73d4bd78b815fa26df1f66e2021-12-02T14:38:33ZMicroglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex10.1038/ncomms109052041-1723https://doaj.org/article/fb70b318d73d4bd78b815fa26df1f66e2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10905https://doaj.org/toc/2041-1723Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.G. O. SipeR. L. Lowery,M-È TremblayE. A. KellyC. E. LamantiaA. K. MajewskaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. O. Sipe R. L. Lowery, M-È Tremblay E. A. Kelly C. E. Lamantia A. K. Majewska Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
description	Microglia play key roles during early neurodevelopment. Here the authors show that microglia are important mediators of ocular dominance plasticity (ODP). Microglia respond to monocular deprivation during the visual critical period, and disrupting microglial P2Y12 purinergic receptor abrogates ODP.
format	article
author	G. O. Sipe R. L. Lowery, M-È Tremblay E. A. Kelly C. E. Lamantia A. K. Majewska
author_facet	G. O. Sipe R. L. Lowery, M-È Tremblay E. A. Kelly C. E. Lamantia A. K. Majewska
author_sort	G. O. Sipe
title	Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
title_short	Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
title_full	Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
title_fullStr	Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
title_full_unstemmed	Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
title_sort	microglial p2y12 is necessary for synaptic plasticity in mouse visual cortex
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/fb70b318d73d4bd78b815fa26df1f66e
work_keys_str_mv	AT gosipe microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex AT rllowery microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex AT metremblay microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex AT eakelly microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex AT celamantia microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex AT akmajewska microglialp2y12isnecessaryforsynapticplasticityinmousevisualcortex
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Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

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