Parkinson's in the bone

Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patients, and what are the relationship (s) of the periphery tissue deficits with the bra...

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Main Authors:	Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei, Wen-Cheng Xiong
Format:	article
Language:	EN
Published:	BMC 2021
Subjects:	Parkinson's disease Bone homeostasis Osteoporosis Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
Online Access:	https://doaj.org/article/fb9cc548fd604b8d828b13e62d3f18f9
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id	oai:doaj.org-article:fb9cc548fd604b8d828b13e62d3f18f9
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spelling	oai:doaj.org-article:fb9cc548fd604b8d828b13e62d3f18f92021-11-08T11:03:28ZParkinson's in the bone10.1186/s13578-021-00702-52045-3701https://doaj.org/article/fb9cc548fd604b8d828b13e62d3f18f92021-11-01T00:00:00Zhttps://doi.org/10.1186/s13578-021-00702-5https://doaj.org/toc/2045-3701Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patients, and what are the relationship (s) of the periphery tissue deficits with the brain pathology (e.g., dopamine neuron loss), are at the beginning stage to be investigated. Notice that both PD and osteoporosis are the products of a complex interaction of genetic and environmental risk factors. Genetic mutations in numerous genes have been identified in patients either with recessive or autosomal dominant PD. Most of these PD risk genes are ubiquitously expressed; and many of them are involved in regulation of bone metabolism. Here, we review the functions of the PD risk genes in regulating bone remodeling and homeostasis. The knowledge gaps in our understanding of the bone-to-brain axis in PD development are also outlined.Lei XiongJin-Xiu PanHao-han GuoLin MeiWen-Cheng XiongBMCarticleParkinson's diseaseBone homeostasisOsteoporosisBiotechnologyTP248.13-248.65Biology (General)QH301-705.5BiochemistryQD415-436ENCell & Bioscience, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Parkinson's disease Bone homeostasis Osteoporosis Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
spellingShingle	Parkinson's disease Bone homeostasis Osteoporosis Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436 Lei Xiong Jin-Xiu Pan Hao-han Guo Lin Mei Wen-Cheng Xiong Parkinson's in the bone
description	Abstract Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patients, and what are the relationship (s) of the periphery tissue deficits with the brain pathology (e.g., dopamine neuron loss), are at the beginning stage to be investigated. Notice that both PD and osteoporosis are the products of a complex interaction of genetic and environmental risk factors. Genetic mutations in numerous genes have been identified in patients either with recessive or autosomal dominant PD. Most of these PD risk genes are ubiquitously expressed; and many of them are involved in regulation of bone metabolism. Here, we review the functions of the PD risk genes in regulating bone remodeling and homeostasis. The knowledge gaps in our understanding of the bone-to-brain axis in PD development are also outlined.
format	article
author	Lei Xiong Jin-Xiu Pan Hao-han Guo Lin Mei Wen-Cheng Xiong
author_facet	Lei Xiong Jin-Xiu Pan Hao-han Guo Lin Mei Wen-Cheng Xiong
author_sort	Lei Xiong
title	Parkinson's in the bone
title_short	Parkinson's in the bone
title_full	Parkinson's in the bone
title_fullStr	Parkinson's in the bone
title_full_unstemmed	Parkinson's in the bone
title_sort	parkinson's in the bone
publisher	BMC
publishDate	2021
url	https://doaj.org/article/fb9cc548fd604b8d828b13e62d3f18f9
work_keys_str_mv	AT leixiong parkinsonsinthebone AT jinxiupan parkinsonsinthebone AT haohanguo parkinsonsinthebone AT linmei parkinsonsinthebone AT wenchengxiong parkinsonsinthebone
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Parkinson's in the bone

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