USP13 negatively regulates antiviral responses by deubiquitinating STING

The cGAS-STING pathway is a DNA sensing mechanism that enables response to viral infection by inducing type 1 interferon expression. Here the authors show a mechanism by which the deubiquitinating enzyme USP13 prevents STING from enabling response to virus.

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Detalles Bibliográficos
Autores principales:	He Sun, Qiang Zhang, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian-Chen Xiong, Yan Wu, Qi-Yun Zhu, Jing Yao, Hong-Bing Shu, Dandan Lin, Bo Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/fbc5fe9e9ef2487986b6042fd5305778
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spelling	oai:doaj.org-article:fbc5fe9e9ef2487986b6042fd53057782021-12-02T17:06:01ZUSP13 negatively regulates antiviral responses by deubiquitinating STING10.1038/ncomms155342041-1723https://doaj.org/article/fbc5fe9e9ef2487986b6042fd53057782017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15534https://doaj.org/toc/2041-1723The cGAS-STING pathway is a DNA sensing mechanism that enables response to viral infection by inducing type 1 interferon expression. Here the authors show a mechanism by which the deubiquitinating enzyme USP13 prevents STING from enabling response to virus.He SunQiang ZhangYing-Ying JingMan ZhangHai-Ying WangZeng CaiTianzi LiuyuZhi-Dong ZhangTian-Chen XiongYan WuQi-Yun ZhuJing YaoHong-Bing ShuDandan LinBo ZhongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q He Sun Qiang Zhang Ying-Ying Jing Man Zhang Hai-Ying Wang Zeng Cai Tianzi Liuyu Zhi-Dong Zhang Tian-Chen Xiong Yan Wu Qi-Yun Zhu Jing Yao Hong-Bing Shu Dandan Lin Bo Zhong USP13 negatively regulates antiviral responses by deubiquitinating STING
description	The cGAS-STING pathway is a DNA sensing mechanism that enables response to viral infection by inducing type 1 interferon expression. Here the authors show a mechanism by which the deubiquitinating enzyme USP13 prevents STING from enabling response to virus.
format	article
author	He Sun Qiang Zhang Ying-Ying Jing Man Zhang Hai-Ying Wang Zeng Cai Tianzi Liuyu Zhi-Dong Zhang Tian-Chen Xiong Yan Wu Qi-Yun Zhu Jing Yao Hong-Bing Shu Dandan Lin Bo Zhong
author_facet	He Sun Qiang Zhang Ying-Ying Jing Man Zhang Hai-Ying Wang Zeng Cai Tianzi Liuyu Zhi-Dong Zhang Tian-Chen Xiong Yan Wu Qi-Yun Zhu Jing Yao Hong-Bing Shu Dandan Lin Bo Zhong
author_sort	He Sun
title	USP13 negatively regulates antiviral responses by deubiquitinating STING
title_short	USP13 negatively regulates antiviral responses by deubiquitinating STING
title_full	USP13 negatively regulates antiviral responses by deubiquitinating STING
title_fullStr	USP13 negatively regulates antiviral responses by deubiquitinating STING
title_full_unstemmed	USP13 negatively regulates antiviral responses by deubiquitinating STING
title_sort	usp13 negatively regulates antiviral responses by deubiquitinating sting
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/fbc5fe9e9ef2487986b6042fd5305778
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USP13 negatively regulates antiviral responses by deubiquitinating STING

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