Improving cancer immunotherapy by targeting IL-1

Interleukin-1 (IL-1) is an inflammatory cytokine associated with tumor invasiveness and metastasis. We recently found that baseline IL-1 in melanomas promoted resistance to immunotherapy by creating an immunosuppressive tumor microenvironment and that IL-1 produced in response to CD40 agonist also i...

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Bibliographic Details
Main Authors: Zhilan Xiao, Shubhra Singh, Manisha Singh
Format: article
Language:EN
Published: Taylor & Francis Group 2021
Subjects:
Online Access:https://doaj.org/article/fbc895f8725448949ed32765c4489559
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