Stereoselective synthesis of a 4-⍺-glucoside of valienamine and its X-ray structure in complex with Streptomyces coelicolor GlgE1-V279S

Abstract Glycoside hydrolases (GH) are a large family of hydrolytic enzymes found in all domains of life. As such, they control a plethora of normal and pathogenic biological functions. Thus, understanding selective inhibition of GH enzymes at the atomic level can lead to the identification of new c...

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Autores principales: Anshupriya Si, Thilina D. Jayasinghe, Radhika Thanvi, Donald R. Ronning, Steven J. Sucheck
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/fc22d1fea7d74f8e857dd73e5c44bc81
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