Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion

The brain is a genomic mosaic shaped by somatic mutations and cellular responses that correct or purge these mutations. Here, by manipulating genome stability during embryonic brain development, authors revealed robust mechanisms that eliminate cells with genome damage from the brain, and the conseq...

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Autores principales: Lei Shi, Adel Qalieh, Mandy M. Lam, Jason M. Keil, Kenneth Y. Kwan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/fc3234fbb7164890a3113aeffc7bddda
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